Coronary heart disease is the leading cause of death in the United States. Its underlying blood vessel disease is atherosclerosis, which involves build-up of the fatty substance containing cholesterol on the interior surfaces of blood vessels, interfering with blood flow and damaging blood vessels. If this fatty build-up becomes severe, it cuts off supplies of oxygen and nutrients to tissue cells, which in turn die. When this occurs in a major coronary artery, the result is a myocardial infarction or heart attack.The risk for atherosclerosis increases with the amount and type of blood lipids (fats), or lipoproteins, available. Elevated serum cholesterol is a primary risk factor for development of atherosclerosis.
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